Top of the pageDecision Point
Nail Infection: Should I Take Antifungal Pills?
You may want to have a say in this decision, or you may simply want to follow your doctor's recommendation. Either way, this information will help you understand what your choices are so that you can talk to your doctor about them.
Nail Infection: Should I Take Antifungal Pills?
1Get the | 2Compare | 3Your | 4Your | 5Quiz | 6Your Summary |
Get the facts
Your options
- Take oral antifungal medicine (antifungal pills) to treat a fungal nail infection.
- Try other treatment, such as antifungal creams, or do nothing.
Key points to remember
- Antifungal pills give you the best chance of curing a severe fungal nail infection.
- If you have liver or heart problems, you should not take antifungal pills. They can cause rare but dangerous side effects, including heart and liver failure.
- You may need testing every 4 to 6 weeks to check for liver, kidney, or heart damage, depending on the antifungal pills you use.
- Sometimes the infection can return after treatment. Your doctor may suggest ways to lower the chances of this happening.
- Other treatments include using antifungal creams, laser treatment, or having your nail removed.
What is a fungal nail infection?
A fungal nail infection occurs when a fungus attacks a fingernail, a toenail, or the skin under the nail, called the nail bed. Fungi (plural of fungus) can attack your nails through small cuts in the skin around your nail or through the opening between your nail and nail bed.
Fungal nail infections are more common in toenails than fingernails. Toenails grow very slowly, giving the fungi more time to develop and get worse. It also takes more time to treat toenails than fingernails.
Yeasts, molds, and different kinds of fungi can cause fungal nail infections. Most are caused by the same type of fungus that causes athlete's foot. Fungi grow best in warm, moist places, and they can spread from person to person. You can get a fungal nail infection from walking barefoot in public showers or pools or from sharing personal items, such as towels and nail clippers. If you have athlete's foot, the fungus can spread from your skin to your nails.
Why would you use antifungal pills to treat a nail infection?
You might use antifungal pills if topical treatments have not worked. A fungal nail infection doesn't go away on its own. And it slowly gets worse over time. An infection may spread into the nail root, where new nail growth begins, and may spread to other nails. The longer you have an infection and the worse it gets, the harder it is to treat.
Severe infections, especially in older people who have had the condition for many years, can cause very thick nails that are hard to trim. They may cause pain or discomfort when you walk. If this happens, it is hard to cure a fungal infection, even with antifungal pills.
Why wouldn't you use antifungal pills to treat a nail infection?
Not all fungal nail infections need treatment with pills. Some people decide not to treat a fungal infection until it is uncomfortable or painful.
Nail infections are hard to treat, and antifungal pills can be costly. There is no guarantee that the pills will work or that the infection won't come back.
The pills used to treat fungal nail infections can cause side effects, including stomach problems and headaches. In rare cases, some of these medicines may cause liver damage and heart failure.
You might think about trying other treatments, such as using an antifungal cream, having laser treatment, or having your nail removed.
How well do antifungal pills work?
Pills to treat fungal nail infections include terbinafine (Lamisil) and medicines called azoles, such as itraconazole (Sporanox) and fluconazole (Diflucan). Studies looking at antifungal medicines found that:footnote 1
- Terbinafine seems to work a little better than azole medicines.
- Terbinafine and azole medicines have about the same rate of side effects.
- The chance of an infection returning is about the same with terbinafine or with azole medicines.
Another antifungal medicine that is used less often is griseofulvin. It seems to work about as well as azole medicines, but griseofulvin causes more side effects.footnote 1
What are the risks of not using pills to treat a nail infection?
If you are healthy, an ongoing fungal nail infection has no serious risks. But over time, the nail may get thick and look bad. It may be painful when you wear shoes or walk.
If you have diabetes or a weak immune system, a fungal infection can lead to a more serious bacterial infection.
Why might your doctor recommend antifungal pills for a fungal nail infection?
Your doctor may advise you to use pills if:
- You have a painful nail infection.
- You have another health problem, such as diabetes, that can cause problems from foot infection.
Compare your options
Compare
What is usually involved? |
| |
|---|---|---|
What are the benefits? |
| |
What are the risks and side effects? |
|
- You take pills every day for several months, or every day for 1 week a month for 2, 3, or 4 months.
- You may need to have blood tests to check that your kidneys and liver are working well.
- Antifungal pills give the best chance of curing a severe fungal nail infection.
- The pills may not work well with other medicines you take, and they could cause problems such as liver damage and heart failure.
- If you have a history of blood or liver disease or you plan to drink alcohol during treatment, these pills are not safe for you.
- Minor side effects include headache, stomach upset, diarrhea, rash, itch, and loss of taste.
- Antifungal pills can be expensive.
- Pills may not work, or the infection may come back.
- Your nail may still look bad after treatment.
Instead, you could:
- Try another treatment, such as an antifungal cream.
- Have the nail removed.
- Do nothing.
- You don't have the risks of taking pills.
- Using creams or removing the nail may clear up your infection, depending on how bad it is.
- Creams may take a long time to work. They will not work as well as pills for a severe infection.
- Your nail infection could get worse, and your nail may fall out.
Personal stories about taking oral antifungal medicine for fungal nail infection
These stories are based on information gathered from health professionals and consumers. They may be helpful as you make important health decisions.
My toenails have always been a little thick and hard to trim, but lately they are starting to really make my feet hurt. I was never sure what the problem was, and now my doctor says it's some type of fungal infection. She says that the medicine may help but that my nail is probably damaged and will never grow back in completely normal. She also mentioned that the medicine is pretty expensive, and that's a concern for me. I'm going to try some other treatment that takes off part of the nail and see if that helps with the pain.
Tom, age 68
I think this fungal toenail infection is the ugliest thing! It's so embarrassing. I always keep my nails trimmed and polished, and this one ugly toenail really bothers me. I asked my doctor about these medicines, and it sounds like they will work well for me, because the problem is just in one of my nails. I just can't believe how long it's going to take to work!
Tammy, age 35
Taking medicines for almost 3 months to treat something that really doesn't bother me? That doesn't make any sense to me. I have a hard enough time remembering everything I need to do at the office, much less remembering to take a pill every day. If the problem gets any worse, then I'll reconsider. For now, I'll just keep that toenail out of sight.
Bonita, age 40
I will always remember my dad's feet. He had these thick, ugly yellow toenails, and he used to wince when he would walk, because they hurt his feet. My doctor says that I could wind up in the same situation. But since I just got this fungal toenail infection in the last year, if we treat it now, we have a good chance of curing it. I'm going to try this oral medicine that takes several months to work. I'm also going to try all the other things he mentioned, like rotating my shoes so they dry, changing my socks more, and using antifungal foot drying powder. I don't care so much what my feet look like, but I sure don't want them to hurt when I'm older.
Bob, age 60
What matters most to you?
Your personal feelings are just as important as the medical facts. Think about what matters most to you in this decision, and show how you feel about the following statements.
Reasons to take antifungal pills
Reasons not to take antifungal pills
I'm worried about my infection getting worse.
I'm not worried about my infection getting worse.
I'm willing to have regular blood tests to check that my liver and kidneys are okay.
I don't want to be bothered with a lot of tests.
I accept the risk of pills.
Taking these pills is too risky for me.
I don't mind taking pills every day for several months.
I don't want to take pills every day.
My other important reasons:
My other important reasons:
Where are you leaning now?
Now that you've thought about the facts and your feelings, you may have a general idea of where you stand on this decision. Show which way you are leaning right now.
Taking antifungal pills
NOT taking antifungal pills
What else do you need to make your decision?
Check the facts
Decide what's next
Certainty
1. How sure do you feel right now about your decision?
Your Summary
Here's a record of your answers. You can use it to talk with your doctor or loved ones about your decision.
Your decision
Next steps
Which way you're leaning
How sure you are
Your comments
Your knowledge of the facts
Key concepts that you understood
Key concepts that may need review
Getting ready to act
Patient choices
Credits and References
| Author | Healthwise Staff |
|---|---|
| Primary Medical Reviewer | Patrice Burgess, MD - Family Medicine |
| Primary Medical Reviewer | Adam Husney, MD - Family Medicine |
| Primary Medical Reviewer | E. Gregory Thompson, MD - Internal Medicine |
| Primary Medical Reviewer | Martin J. Gabica, MD - Family Medicine |
| Specialist Medical Reviewer | Ellen K. Roh, MD - Dermatology |
Nail Infection: Should I Take Antifungal Pills?
- Get the facts
- Compare your options
- What matters most to you?
- Where are you leaning now?
- What else do you need to make your decision?
1. Get the Facts
Your options
- Take oral antifungal medicine (antifungal pills) to treat a fungal nail infection.
- Try other treatment, such as antifungal creams, or do nothing.
Key points to remember
- Antifungal pills give you the best chance of curing a severe fungal nail infection.
- If you have liver or heart problems, you should not take antifungal pills. They can cause rare but dangerous side effects, including heart and liver failure.
- You may need testing every 4 to 6 weeks to check for liver, kidney, or heart damage, depending on the antifungal pills you use.
- Sometimes the infection can return after treatment. Your doctor may suggest ways to lower the chances of this happening.
- Other treatments include using antifungal creams, laser treatment, or having your nail removed.
What is a fungal nail infection?
A fungal nail infection occurs when a fungus attacks a fingernail, a toenail, or the skin under the nail, called the nail bed. Fungi (plural of fungus) can attack your nails through small cuts in the skin around your nail or through the opening between your nail and nail bed.
Fungal nail infections are more common in toenails than fingernails. Toenails grow very slowly, giving the fungi more time to develop and get worse. It also takes more time to treat toenails than fingernails.
Yeasts, molds, and different kinds of fungi can cause fungal nail infections. Most are caused by the same type of fungus that causes athlete's foot. Fungi grow best in warm, moist places, and they can spread from person to person. You can get a fungal nail infection from walking barefoot in public showers or pools or from sharing personal items, such as towels and nail clippers. If you have athlete's foot, the fungus can spread from your skin to your nails.
Why would you use antifungal pills to treat a nail infection?
You might use antifungal pills if topical treatments have not worked. A fungal nail infection doesn't go away on its own. And it slowly gets worse over time. An infection may spread into the nail root, where new nail growth begins, and may spread to other nails. The longer you have an infection and the worse it gets, the harder it is to treat.
Severe infections, especially in older people who have had the condition for many years, can cause very thick nails that are hard to trim. They may cause pain or discomfort when you walk. If this happens, it is hard to cure a fungal infection, even with antifungal pills.
Why wouldn't you use antifungal pills to treat a nail infection?
Not all fungal nail infections need treatment with pills. Some people decide not to treat a fungal infection until it is uncomfortable or painful.
Nail infections are hard to treat, and antifungal pills can be costly. There is no guarantee that the pills will work or that the infection won't come back.
The pills used to treat fungal nail infections can cause side effects, including stomach problems and headaches. In rare cases, some of these medicines may cause liver damage and heart failure.
You might think about trying other treatments, such as using an antifungal cream, having laser treatment, or having your nail removed.
How well do antifungal pills work?
Pills to treat fungal nail infections include terbinafine (Lamisil) and medicines called azoles, such as itraconazole (Sporanox) and fluconazole (Diflucan). Studies looking at antifungal medicines found that:1
- Terbinafine seems to work a little better than azole medicines.
- Terbinafine and azole medicines have about the same rate of side effects.
- The chance of an infection returning is about the same with terbinafine or with azole medicines.
Another antifungal medicine that is used less often is griseofulvin. It seems to work about as well as azole medicines, but griseofulvin causes more side effects.1
What are the risks of not using pills to treat a nail infection?
If you are healthy, an ongoing fungal nail infection has no serious risks. But over time, the nail may get thick and look bad. It may be painful when you wear shoes or walk.
If you have diabetes or a weak immune system, a fungal infection can lead to a more serious bacterial infection.
Why might your doctor recommend antifungal pills for a fungal nail infection?
Your doctor may advise you to use pills if:
- You have a painful nail infection.
- You have another health problem, such as diabetes, that can cause problems from foot infection.
2. Compare your options
| Take antifungal pills | Don't take antifungal pills | |
|---|---|---|
| What is usually involved? |
| Instead, you could:
|
| What are the benefits? |
|
|
| What are the risks and side effects? |
|
|
Personal stories
Personal stories about taking oral antifungal medicine for fungal nail infection
These stories are based on information gathered from health professionals and consumers. They may be helpful as you make important health decisions.
"My toenails have always been a little thick and hard to trim, but lately they are starting to really make my feet hurt. I was never sure what the problem was, and now my doctor says it's some type of fungal infection. She says that the medicine may help but that my nail is probably damaged and will never grow back in completely normal. She also mentioned that the medicine is pretty expensive, and that's a concern for me. I'm going to try some other treatment that takes off part of the nail and see if that helps with the pain."
— Tom, age 68
"I think this fungal toenail infection is the ugliest thing! It's so embarrassing. I always keep my nails trimmed and polished, and this one ugly toenail really bothers me. I asked my doctor about these medicines, and it sounds like they will work well for me, because the problem is just in one of my nails. I just can't believe how long it's going to take to work!"
— Tammy, age 35
"Taking medicines for almost 3 months to treat something that really doesn't bother me? That doesn't make any sense to me. I have a hard enough time remembering everything I need to do at the office, much less remembering to take a pill every day. If the problem gets any worse, then I'll reconsider. For now, I'll just keep that toenail out of sight."
— Bonita, age 40
"I will always remember my dad's feet. He had these thick, ugly yellow toenails, and he used to wince when he would walk, because they hurt his feet. My doctor says that I could wind up in the same situation. But since I just got this fungal toenail infection in the last year, if we treat it now, we have a good chance of curing it. I'm going to try this oral medicine that takes several months to work. I'm also going to try all the other things he mentioned, like rotating my shoes so they dry, changing my socks more, and using antifungal foot drying powder. I don't care so much what my feet look like, but I sure don't want them to hurt when I'm older."
— Bob, age 60
3. What matters most to you?
Your personal feelings are just as important as the medical facts. Think about what matters most to you in this decision, and show how you feel about the following statements.
Reasons to take antifungal pills
Reasons not to take antifungal pills
I'm worried about my infection getting worse.
I'm not worried about my infection getting worse.
I'm willing to have regular blood tests to check that my liver and kidneys are okay.
I don't want to be bothered with a lot of tests.
I accept the risk of pills.
Taking these pills is too risky for me.
I don't mind taking pills every day for several months.
I don't want to take pills every day.
My other important reasons:
My other important reasons:
4. Where are you leaning now?
Now that you've thought about the facts and your feelings, you may have a general idea of where you stand on this decision. Show which way you are leaning right now.
Taking antifungal pills
NOT taking antifungal pills
5. What else do you need to make your decision?
Check the facts
1. Do antifungal pills give you the best chance of curing severe fungal nail infections?
- Yes
- No
- I'm not sure
2. Can antifungal pills cause serious side effects?
- Yes
- No
- I'm not sure
3. Is taking antifungal pills the only way to treat a fungal nail infection?
- Yes
- No
- I'm not sure
Decide what's next
1. Do you understand the options available to you?
2. Are you clear about which benefits and side effects matter most to you?
3. Do you have enough support and advice from others to make a choice?
Certainty
1. How sure do you feel right now about your decision?
2. Check what you need to do before you make this decision.
- I'm ready to take action.
- I want to discuss the options with others.
- I want to learn more about my options.
| By | Healthwise Staff |
|---|---|
| Primary Medical Reviewer | Patrice Burgess, MD - Family Medicine |
| Primary Medical Reviewer | Adam Husney, MD - Family Medicine |
| Primary Medical Reviewer | E. Gregory Thompson, MD - Internal Medicine |
| Primary Medical Reviewer | Martin J. Gabica, MD - Family Medicine |
| Specialist Medical Reviewer | Ellen K. Roh, MD - Dermatology |
Note: The "printer friendly" document will not contain all the information available in the online document some Information (e.g. cross-references to other topics, definitions or medical illustrations) is only available in the online version.
Current as of: February 23, 2018
